Thursday, November 26, 2020

Genes, Brain Function And Mood In Depression


Depression runs in families. There has been some debate whether this is the result of genetics (a depression gene is inherited from a depressed parent) or whether it is more environmental (the negative effects of living with a depressed parent). It turns out that both play a substantial role.

The Evidence

Bipolar disorder, in which a person usually has episodes of both mania and depression, best illustrates the genetic connection. This disorder affects about 1 percent of the general population. But a person with a parent, sibling or child who has been manic has a 15% chance of developing this disorder during his or her lifetime. If both parents have bipolar disorder, there is a 30% chance that one or more of their children will have it. If one identical twin has the disorder, there is a 40% to 70% chance that the other will too.  

This last statistic is interesting, because it shows that genetic inheritance is not all there is to it. Identical twins have identical genes, so you would expect an even higher matching among twins. But the risk is not 100%. So, other factors such as environmental influences (including life experiences) must have some effect on whether or how bipolar disorder occurs.

The chance of having major depression is also higher for people who have relatives with the disorder, although the link is not as strong as it is for bipolar disorder. In milder forms of depression, genes may be less influential. Scientists believe there are many genes controlling mood and influencing depression.

How Genes Control Brain Function

Genes supply the instructions for how the brain develops from conception through death and for everything the brain does in between. There are huge numbers of instructions. Genetics controls an almost infinite variety of processes. Chemicals relay messages inside cells and between cells. There is complicated circuitry along which millions of signals travel. The circuits group into major pathways with specific jobs, such as regulating mood or hanging on to memories.  

It is still unknown where depression “lives” in the brain, but advances in genetics and in new technology (specifically the ability to take pictures of the brain at work) are likely to give detailed answers in the coming years.

Medically trained in the UK. Writes on the subjects of injuries, healthcare and medicine. Contact me

9 Ways to Build a Child’s Self Esteem

How can parents and teachers help be sure that children will be responsible for their education, free-time and overall well-being? Success in...


Pedicures are a popular beauty treatment, which may be carried out at a spa, beauty salon, or in the comfort of your...

Vegan Grocery Shopping: Food Aisles

If you’ve been lurking in the depths of the backs of grocery stores, you might not know that there are aisles filled...

Bates Method

The Bates method for better eyesight was developed by ophthalmologist William Bates in 1920. Bates believed poor...

36 Natural Skin Care Remedies

Natural Herbal Remedies For Healthier Skin And Preventing Wrinkles Natural remedies for glowing skin include herbal remedies as well...

Recognizing When It Is More Than Stress

It is normal to be nervous in stressful situations. But stressors, such as the breakup of a marriage or the loss of...